VITAMIN D3 + K2 (MK7)

VITAMIN D3 AND ACE2

Inhibits mRNA Vaccine & COVID “Spike Protein” Body Organ Cell Attachment, Penetration, and Replication!

Anti-Pathogen, Excess Cytokine Inhibitor, Anti-inflammatory, Inhibits Long-Term Health Issues!

The ACE2 receptor is expressed in the lung, heart, kidney, and intestinal cells. The ACE2 enzyme is made of an N‐terminal peptidase domain (PD) and a C‐terminal collectrin‐like domain, ending in a transmembrane helix. The SARS‐CoV‐2 virus interacts with the PD of ACE2, which is known to have a claw‐like structure for host cell entry. When the S‐protein of SARS‐CoV‐2 merges with the ACE2 receptors, transmembrane serine protease 2 proteolytically cleaves ACE2 and allows the virus particles to enter the host cell, replicate, and have cell‐to‐cell transmission. In vitro studies demonstrated a direct correlation between the expression of ACE2 and increase in the infection of the lungs and other tissues by SARS‐CoV‐2. Renin-angiotensin-aldosterone system inhibitors (RAAS) can block the ACE2 receptor to which S protein latches onto can prevent viral entry into the heart and lungs and protects them from being injured by the SARS‐CoV‐2 infection.

Reference:

(Grant, 2020). Grant WB, Lahore H, McDonnell SL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. Published 2020 Apr 2. doi:10.3390/nu12040988 https://pubmed.ncbi.nlm.nih.gov/32252338/

 

VITAMIN D3

Vitamin D3 enhances cellular immunity, in part by reducing the cytokine storm induced by the innate immune system. The innate immune system generates both pro-inflammatory and anti-inflammatory cytokines in response to viral and bacterial infections, as observed in COVID-19 patients. Vitamin D3 can reduce the production of pro-inflammatory Th1 cytokines, such as tumor necrosis factor α and interferon γ. Administering vitamin D3 reduces the expression of pro-inflammatory cytokines and increases the expression of anti-inflammatory cytokines by macrophages.

Vitamin D3 supplementation also enhances the expression of genes related to antioxidation (glutathione reductase and glutamate–cysteine ligase modifier subunit). The increased glutathione production spares the use of ascorbic acid (vitamin C), which has antimicrobial activities, and has been proposed to prevent and treat COVID-19. (Grant, 2020).

* Vitamin D₃ deficiency may be a leading cause in the death of COVID-19 patients:

• • Vitamin D3 https://pubmed.ncbi.nlm.nih.gov/32252338/

 

VITAMIN K2

Anti-Pathogen, Excess Cytokine Inhibitor, Anti-inflammatory, Inhibits Long-Term Health Issues!

The evidence suggests a correlation between vitamin K2 deficiency in COVID patients and worsens clinical course due to the enhanced fiber mineralization. It has been reported that vitamin K2 deficiency is strongly associated with admission to ICU. In addition, the low levels of vitamin K2 seem to contribute to increasing levels of IL-6 cytokine protein release and Th2 cytokine spike protein storm activation (Parisi, 2021).

Studies backed by Kappa Bioscience found that deficiency in either vitamin D3 or vitamin K2 increased the risk of COVID-19 infection. The research also revealed more severe outcomes if COVID-19 patients are deficient in both nutrients. He details that vitamin D activates immune cells at the beginning of an infection and helps to block a key inflammatory chemical mediator – nuclear factor (NF) kappa B. Meanwhile, the primary modulator of inflammation is vitamin K2. “Vitamin K2 has been shown to inhibit NF kappa B as well as other interleukins that lead to the cytokine storm in COVID-19 infections.” (Green, 2021).

Recent studies evaluating serum K2 levels in COVID-19 hospitalized patients found that patients with poor outcomes of COVID-19 had the lowest levels of vitamin K2. In comparison, people tested negative for SARS-CoV-2 infection showed adequate vitamin K2 levels. (Kappa, 2020).

Reference:

(Parisi, 2021). Parisi GF, Carota G, Castruccio Castracani C, et al. Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature. Int J Mol Sci. 2021;22(5):2465. Published 2021 Feb 28. doi:10.3390/ijms22052465 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957644/

(Green, 2021). Nutrition Insight: Kappa Bioscience uncovers vitamin K2’s unique role in immunity and COVID-19. Retrieved on 08/08/21 online from https://www.nutritioninsight.com/news/kappa-bioscience-uncovers-vitamin-k2s-unique-role-in-immunity-and-covid-19.html

(Kappa, 2020). Kappa Bioscience: COVID-19 and cardiovascular health: the role of K2 in high vitamin D supplementation. Retrieved on 08/16/21 online from https://www.nutraceuticalbusinessreview.com/news/article_page/COVID-19_and_cardiovascular_health_the_role_of_K2_in_high_vitamin_D_supplementation/171381

 

MAGNESIUM:

Helps Enzymes metabolize Vitamin D3 & K2

Given that vitamin D3 is an immunoregulating hormone and can be considered safe when supplementing it together with K2, supplementation of magnesium (200–250 mg/day) should also be considered, as all enzymes that metabolize vitamin D3 seem to require magnesium. (Goddek, 2020).

Reference:

(Goddek. 2020). Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate. Int J Infect Dis. 2020;99:286-290. doi:10.1016/j.ijid.2020.07.080 https://pubmed.ncbi.nlm.nih.gov/32768697/